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KMID : 0364219670100010017
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Korean Journal of Zoology
1967 Volume.10 No. 1 p.17 ~ p.20
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Studies on the Radiosensitivity of the Chromosomes in Cultured Human Cells
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Kang Yung-Sun
Kim Yung-Jin
Lee Chung-Keel
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Abstract
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The present experiment was perform to investigate the frequencies of chromosome aberration with special regard to the chromosome groups and the various time intervals after X-irradiation (60 r) in ormal human foetus cells grown in culture. The cytological preparations were prepared at every 5 through 30 hours after X-irradiation by the air-drying method. 1. The frequencies of chormosome aberration are on the whole decreased as tie elapses after irradiation and this is thought to be due to gradual recovery with time . However, a slight increase in frequencies is observed at 25 and 30 hours after irradiation respectively. This shows that the cells at the these periods are more sensitivity to X-irradation , and those cells are thought to be at G2 and late S stage at the time of irradiation respectively, so t is evident that G2 and late S stages a the time of irradiation respectively , so it is evident that G2 and late S stages are more sensitive to X-irradiation than any other stages. 2. The frequencies of chormosome aberration are decreased in descending order of chormosome group number. The differences among these frequencies are highly significant statistically . Therefore it can be concluded that there is a highly significant difference in radiosensitivity among chromosome groups. that is, the chromosomes of the group A are the most radiosensitive , followed by B, C, D ,E and G in descending order.
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